Non- Insulin based diabetes therapies

Type 2 Diabetes, also known as adult-onset diabetes, is a type of diabetes characterised by high blood sugar, insulin resistance, and a relative lack of insulin. Symptoms may also include increased hunger, fatigue, and unhealed sores. Long-term complications of diabetes include heart disease, strokes, diabetic retinopathy (which can lead to blindness), kidney failure, and poor blood flow in the limbs, which can lead to amputations. The primary metabolic effect of this is to inhibit glucose reabsorption in the kidney, lowering blood sugar. They work by inhibiting the sodium-glucose transport protein 2 (SGTP2) (SGLT2). Type II diabetes mellitus is treated with SGLT2 inhibitors (T2DM).

  • Nutrition and diet
  • Oral therapies: metformin, sensitizers and other non-secretagogues
  • SGLT inhibitors
  • Incretin-based therapies
  • Novel agents

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